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KMID : 0882420060710020224
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Korean Journal of Medicine
2006 Volume.71 No. 2 p.224 ~ p.228
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A case of chinese herb nephropathy induced by aristolochia fangchi
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Lee Jae-Wook
Sohn Min-Jung
Heo Nam-Joo
Joo Kwon-Wook
Jung Yoon-Chul
Lee Jung-Sang
Han Jin-Suk
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Abstract
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Chinese herb nephropathy (CHN) is characterized by progressive tubulointerstitial nephritis and development of renal failure in a couple of years after diagnosis. Aristolochic acid (AA) is believed to be associated with the development of CHN. The authors report a case of CHN in which AA in the herb regimen was identified by high-performance liquid chromatography (HPLC). A 32-year-old female presented with nausea, vomiting and generalized weakness. She had been taking Chinese herbs for symptomatic care. Clinical and laboratory examinations revealed Fanconi syndrome, renal failure, and severe anemia. Renal biopsy showed severe tubulointerstitial nephritis with moderate tubular atrophy and interstitial fibrosis. She developed end-stage renal failure 4 months after diagnosis. The herb she had been taking was Aristolochia fangchi. HPLC technique was used to identify AA and to measure its concentration in the herb. From the clinical and laboratory data, the patient was diagnosed with CHN caused by aristolochic acid.
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KEYWORD
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Aristolochic acids, Aristolochia, Tubulointerstitial nephritis
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